Book DescriptionA Textbook of Modern Toxicology is a unique resource that provides both students and practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses in environmental, pharmacological, medical, and veterinary toxicology, this essential text features chapters written by experts who address a range of key topics. The Fourth Edition includes additional chapters on new approaches to toxicology - molecular methods (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and systems biology - and continues the legacy of its predecessors to provide up-to-date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity testing, ecological risk assessment, and many other areas of toxicology that help foster a solid comprehension of the field. Also featured in the Fourth Edition are end-of-chapter questions and a Solutions Manual available separately for academic adopters.
Table of Contents Part I. Introduction. 1. Introduction. 2. Introduction to Biochemical and Molecular Methods in Toxicology. Part II. Classes of Toxicants. 3. Exposure Classes, Toxicants in Air, Water, Soil, Domestic and Occupational Settings. 4. Classes of Toxicants: Use Classes. Part III. Toxicant Processing In Vivo. 5. Absorption and Distribution of Toxicants. 6. Metabolism of Toxicants. 7. Reactive Metabolites. 8. Chemical and Physiological Influences on Xenobiotic Metabolism. 9. Elimination of Toxicants. Part IV. Toxic Action. 10. Acute Toxicity. 11. Chemical Carcinogenesis. 12. Teratogenesis. Part V. Organ Toxicity. 13. Hepatotoxicity. 14. Nephrotoxicity. 15. Toxicology of the Nervous System. 16. Reproductive System. 17. Endocrine System. 18. Respiratory Toxicity. 19. Immunotoxicity. Part VI. Applied Toxicology. 20 Toxicity Testing. 21. Forensic and Clinical Toxicology. 22. Prevention of Toxicity. 23 Human Health Risk Assessment. Part VII. Environmental Toxicology. 24. Toxicant Analysis. 25. Basics of Environmental Toxicology. 26. Transport and Fate of Toxicants in the Environment. 27. Ecological Risk Assessment. Part VIII. New Approaches in Toxicology. 28. Perspectives on Informatics in Toxicology. 29. Future Considerations. Glossary. Index.