Book Description
Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding.
This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.
Table ContentsIntroductionShayne Cox GadThe MouseShayne Cox Gad, Charlie Clifford, and Dawn GoodmanThe RatMark D. Johnson, Shayne Cox Gad, and Christopher J. KemperThe HamsterShayne Cox Gad and Frederick G. HessThe Guinea PigShayne Cox Gad and John Peckham (deceased)RabbitClare M. Salamon and Shayne Cox GadThe FerretDaniel E. McLain and Shayne Cox GadThe DogShayne Cox Gad, Mark Morse, and Christopher J. KemperPrimatesMark D. Walker, Michael V. Templin, John C. Bernal, Stewart B. Jacobson, and Shayne Cox GadThe MinipigShayne Cox Gad and Alain Stricker-KrongradAlternative SpeciesShayne Cox GadClinical Pathology of Laboratory AnimalsNiraj K. Tripathi and Robert L. HallTelemetry in Nonclinical Drug Safety Assessment StudiesR. Dustan (Dusty) SarazanMolecular Imaging Techniques in Laboratory AnimalsZheng J. Wang, Ting-Tung A. Chang, Richard Slauter, Stephen R. Porter, Avinash Srivatsan, and Xiaoyuan ChenGenetically Modified Animal ModelsJoAnn SchuhModel Selection and Scaling (Allometry)Shayne Cox GadSusceptibility FactorsShayne Cox GadLaws, Regulations, and Guidelines for Animal Care and Use in ResearchCharles B. Spainhour and Laurie M. SerfilippiNecropsy and Gross PathologyCharles B. Spainhour