Book Description

Medicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations.

• Adopts a novel biosynthetic theme rather than a traditional descriptive approach
• Includes extensive further reading at the end of the chapter
• Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal
   products
• Includes the latest developments in the field
• New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids
• User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations

Booknews

This comprehensive guide to pharmacognosy, the scientific study of natural health remedies from herbs, animal products, and inorganic materials, is directed primarily toward undergraduate students— whether or not such material is integrated with traditional pharmacy courses. Dewick (pharmaceutical sciences, U. of Nottingham, UK) provides a foundation in natural product chemistry/phytochemistry and nomenclature before proceeding to coverage of the primary and secondary metabolism of the reactions of these diverse substances; and the pathways involved in the biosynthesis of several classes of popular natural medicines represented by echinacea, kava, feverfew, taxol, alkaloids, garlic, and various vitamins. The chapters include molecular structure diagrams, boxed material, and further reading. Annotation c. Book News, Inc., Portland, OR (booknews.com)
A text for an undergraduate pharmacy course reflecting the recent tendency to teach about pharmaceuticals derived from plants, antibiotics from microbials, and steroidal and prostanoid drugs from animals as a single subject. Pivots on the notion of biosynthesis as the metabolic sequence leading to various selected classes of natural products. Applies fundamental chemical principles and shows the relationships between the various structures encountered in nature to provide a rationale for natural products. Seeks more to engender an understanding of the structures and how living organisms put them together than to transfer a mass of descriptive information. The material is ample and diverse enough to be selected from to tailor a specific course. References are not only chapter-specific, but classified into the several compounds discussed. Annotation c. by Book News, Inc., Portland, Or.

Table of Contents

 1  About this Book, and How to Use it

 2  Secondary Metabolism: The Building Blocks and Construction Mechanisms
      Primary and Secondary Metabolism
      The Building Blocks
      The Construction Mechanisms
      Some Vitamins Associated with the Construction Mechanisms

 3  The Acetate Pathway: Fatty Acids and Polyketides
      Saturated Fatty Acids
      Unsaturated Fatty Acids
      Acetylenic Fatty Acids
      Branched-Chain Fatty Acids
      Prostaglandins
      Thromboxanes
      Leukotrienes
      Aromatic Polyketides
      Macrolides and Polyethers
      Cyclization Through Diels-Alder Reactions
      Genetic Manipulation of the Acetate Pathway

 4  The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids
      Aromatic Amino Acids and Simple Benzoic Acids
      Cinnamic Acids
      Lignans and Lignin
      Phenylpropenes
      Benzoic Acids from C[subscript 6]C[subscript 3] Compounds
      Coumarins
      Styrylpyrones
      Flavonoids and Stillbenes
      Flavonolignans
      Isoflavonoids
      Terpenoid Quinones

 5  The Mevalonate and Deoxyxylulose Phosphate Pathways: Terpenoids and Steroids
      Hemiterpenes (C[subscript 5])
      Monoterpenes (C[subscript 10])
      Irregular Monoterpenes
      Iridoids (C[subscript 10])
      Sesquiterpenes (C[subscript 15])
      Diterpenes (C[subscript 20])
      Sesterterpenes (C[subscript 25])
      Triterpenes (C[subscript 30])
      Tetraterpenes (C[subscript 40])
      Higher Terpenoids
      Steroids

 6  Alkaloids
      Alkaloids Derived from Ornithine
      Alkaloids Derived from Lysine
      Alkaloids Derived from Nicotinic Acid
      Alkaloids Derived from Tyrosine
      Alkaloids Derived from Tryptophan
      Alkaloids Derived from Anthranilic Acid
      Alkaloids Derived from Histidine
      Alkaloids Derived by Amination Reactions
      Purine Alkaloids

 7  Peptides, Proteins, and Other Amino Acid Derivatives
      Peptides and Proteins
      Ribosomal Peptide Biosynthesis
      Peptide Hormones
      Nonribosomal Peptide Biosynthesis
      Peptide Antibiotics
      Peptide Toxins
      Modified Peptides: Penicillins, Cephalosporins, and Other [beta]-Lactams
      Cyanogenic Glycosides
      Glucosinolates
      Cysteine Sulphoxides

 8  Carbohydrates
      Monosaccharides
      Oligosaccharides
      Polysaccharides
      Aminosugars
      Aminoglycosides

Index