Book DescriptionMedicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions: • a comprehensive treatment of plant, microbial, and animal natural products in one volume• extensive use of chemical schemes with annotated mechanistic explanations• cross-referencing to emphasize links and similarities• boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of actionMedicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.
Table of Contents1 About this Book, and How to Use it 2 Secondary Metabolism: The Building Blocks and Construction Mechanisms Primary and Secondary Metabolism The Building Blocks The Construction Mechanisms Some Vitamins Associated with the Construction Mechanisms 3 The Acetate Pathway: Fatty Acids and Polyketides Saturated Fatty Acids Unsaturated Fatty Acids Acetylenic Fatty Acids Branched-Chain Fatty Acids Prostaglandins Thromboxanes Leukotrienes Aromatic Polyketides Macrolides and Polyethers Cyclization Through Diels-Alder Reactions Genetic Manipulation of the Acetate Pathway 4 The Shikimate Pathway: Aromatic Amino Acids and Phenylpropanoids Aromatic Amino Acids and Simple Benzoic Acids Cinnamic Acids Lignans and Lignin Phenylpropenes Benzoic Acids from C[subscript 6]C[subscript 3] Compounds Coumarins Styrylpyrones Flavonoids and Stillbenes Flavonolignans Isoflavonoids Terpenoid Quinones 5 The Mevalonate and Deoxyxylulose Phosphate Pathways: Terpenoids and Steroids Hemiterpenes (C[subscript 5]) Monoterpenes (C[subscript 10]) Irregular Monoterpenes Iridoids (C[subscript 10]) Sesquiterpenes (C[subscript 15]) Diterpenes (C[subscript 20]) Sesterterpenes (C[subscript 25]) Triterpenes (C[subscript 30]) Tetraterpenes (C[subscript 40]) Higher Terpenoids Steroids 6 Alkaloids Alkaloids Derived from Ornithine Alkaloids Derived from Lysine Alkaloids Derived from Nicotinic Acid Alkaloids Derived from Tyrosine Alkaloids Derived from Tryptophan Alkaloids Derived from Anthranilic Acid Alkaloids Derived from Histidine Alkaloids Derived by Amination Reactions Purine Alkaloids 7 Peptides, Proteins, and Other Amino Acid Derivatives Peptides and Proteins Ribosomal Peptide Biosynthesis Peptide Hormones Nonribosomal Peptide Biosynthesis Peptide Antibiotics Peptide Toxins Modified Peptides: Penicillins, Cephalosporins, and Other [beta]-Lactams Cyanogenic Glycosides Glucosinolates Cysteine Sulphoxides 8 Carbohydrates Monosaccharides Oligosaccharides Polysaccharides Aminosugars Aminoglycosides Index