For over half a century, "Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry" has served the discipline of medicinal chemistry for both graduate and undergraduate pharmacy and chemistry students as well as practicing pharmacists. Fully updated for the Twelfth Edition, this book begins with the fundamental principles of chemistry, biochemistry, and biology that underlie the discipline of medicinal chemistry. These principles are then applied to understanding the properties, mode of action, therapeutic applications, and limitations of various pharmaceutical agents. The subject matter is organized by pharmaceutical and therapeutic classes, providing a bridge between the basic sciences and clinical practice. This text contains many tables for quick reference to names, formulations, dosages, and applications. This edition includes chapter review questions and cases. A companion website provides online updates of medicinal chemistry structures and an image bank for faculty.
Table of Contents
1. Introduction
2. Drug Design Strategies
3. Metabolic Changes of Drugs and Related Organic Compounds
4. Biotechnology and Drug Discovery
5. Immunobiologicals
6. Anti-infective Agents
7. Antimalarials
8. Antibacterial Antibiotics
9. Antiviral Agents
10. Antineoplastic Agents
11. Agents for Diagnostic Imaging
12. Central Nervous System Depressant
13. Central Dopaminergic Signaling Agents
14. Anticonvulsants
15. Central Nervous System Stimulants
16. Adrenergic Agents
17. Cholinergic Drugs and Related Agents
18. Drugs Acting on the Renal System
19. Cardiovascular Agents
20. Hormone-Related Disorders: Nonsteroidal Therapies
21. Agents Treating Bone Disorders
22. Anesthetics
23. Histamine and Antihistaminic Agents
24. Analgesics
25. Steroids Hormones ane Therapeutically Related Compunds
26. Prostaglandins, Leukotrienes, and Essential Fatty Acids
27. Proteins, Enzymes and Peptide Hormones
28. Vitamins
29. An Introduction to the Medicinal Chemistry of Herbs
Appendix Calculated Log P, Log D and pKa
Index
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