Book DescriptionThe definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy.This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.< FONT>
TABLE OF CONTENTS
Part Ⅰ : Basic Concepts And Principles 1. General Principles of Clinical Pharmacokinetics 2. Guidelines for collection and Analysis of Pharmacokinetic Data 3. Critical Evaluation of Methods for Therapeutic Drug Monitoring 4. Analysis of Pharmacokinetic Data for Individualizing Drug Dosage Regimens 5. Pharmacodynamics 6. Influence of Protein Binding and Use of Unbound (Free) Drug Concentrations 7. Drug Metabolism, Trasport, and the Influence of Hepatic Disease 8. Application of Pharmacogenetic Principles to Clinical Pharmacology 9. Influence of Renal Function and Dialysis on Drug Disposition 10. Special Pharmacokinetic and Pharmacodynamic Considerations in Children 11. Special Pharmacokinetic Considerations in the Obese 12. Dietary Influences on Drug Disposition Part Ⅱ : Respiratory disorders 13. Asthma Management 14. Aminoglycosides 15. Vancomycin 16. Microbiologic, Clinical, and Economic Outcomes of Dual Individualized Dosing of Antimicrobial Agents 17. Antivirals for HIV 18. Digoxin 19. Clinical Pharmacokinetics of Oral Antiarrhythmic Drugs 20. Phenytoin 21. Antiepileptic Drugs 22. Cyclosporine 23. Tacrolimus 24. Mycophenolic Acid 25. Sirolimus 26. Anticancer Agents 27. Heparin-UFH and LMWH 28. Warfarin 29. Nonsteroidal Anti-Inflammatory Drugs and Coxibs 30. Cyclic Antidepressants 31. Lithium 32. AntipsychoticsAppendix : A Critical Assessment of the Outcomes of Therapeutic Drug Monitoring