Book Descriptionelandmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics―now fully updated.- Explains how to detect clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them- Helps you critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency- Chapters have been revised to reflect the latest clinical perspectives on drug performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapyThe field’s leading text for more than three decades, Applied Biopharmaceutics & Pharmacokinetics gets you up to speed on the basics of the discipline like no other resource. Practical problems and clinical examples with discussions are integrated within each chapter to help you apply principles to patient care and drug consultation situations. In addition, outstanding pedagogy, including chapter objectives, chapter summaries, and FAQs, plus additional application questions, identify and focus on key concepts. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics shows you how to use raw data and formulate the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination. The book also helps you work with pharmacokinetic and biopharmaceutic parameters to design and evaluate dosage regimens of drugs. In the seventh edition of this must-have interactive learning tool, most of the chapters are updated to reflect our current understanding of complex issues associated with safe and efficacious drug therapy.
Table of Contents1. Introduction to Biopharmaceutics and Pharmacokinetics2. Mathematical Fundamentals in Pharmacokinetics3. Biostatistics4. One-Compartment Open Model: Intravenous Bolus Administration5. Multicompartment Models: Intravenous Bolus Administraion 6. Intravenous Infusion7. Drug Elimmination, Clearance, and Renal Clearance8. Pharmacokinetics of Oral Absorption9. Multiple-Dosage Regimens10. Nonlinear Pharmacokinetics11. Physiologic Drug Distribution and Protein Binding12. Drug Elimination and Hepatic Clearance13. Pharmacokinetics and Drug Metabolism14. Physiology Factors Related to Drug Absorption 15. Biopharmaceutics Considerations in Drug Product Design and In Vitro Drug Product Performance16. Drug Product Performance, In Vivo: Bioavaliability and Bioequivalence17. Biopharmaceutical Aspects of the Active Pharmaceutical Ingredient and Pharmaceutical Equicalence18. Impact of Biopharmaceutics on Drug Product Quality and Clincal Efficacy19. Modified-Release Drug Products and Drug Devices20. Targeted Drug Delivevy Systems and Biotechnological Products21. Relationship Between Pharmacokinetics and Pharmacodynamics22. Application of Pharmacokinetics to Clinical Situations23. Applicarion of Pharmacokinetics to specific Populations: Gericatric, Obese, and Pediatric Patients24. Dose Adjustment in Renal and Hepatic Disease25. Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental Analtsis