Features
•Provides a list of the most common medications associated with adverse drug interactions
•Serves as a comprehensive, clinically based, and user-friendly guide for the early detection of reactions
•Covers nutritional supplements and over-the-counter therapeutic agents
•Provides instructions for monitoring patients when adverse interactions occur
•Provides summaries of the mechanisms underlying interactions particularly the increasingly recognized role of genetics and the ethnic differences in pharmacokinetics
Summary
Adverse Drug Interactions: A Handbook for Prescribers assists clinicians by providing key information on potential adverse effects that can result from prescribing two or more drugs for simultaneous use.
Interactions that are likely to give rise to life-threatening conditions, and which must therefore be completely avoided, are clearly highlighted. Less threatening but nonetheless important interactions necessitating practical measures, such as frequent monitoring and advice to patients, are also discussed.
Presented in a user-friendly format, the book is organised by drug class and provides a brief summary of the mechanism underlying a particular interaction, alternative drugs lacking the same reactions that may be considered, and instructions for monitoring patients when adverse effects occur.
All interactions listed in the previous edition have been reviewed and updated using the latest information available. The clinical reality of the widespread use of potent medicines, whether allopathic, herbal or traditional, has led to the inclusion of a chapter specifically addressing over-the-counter drugs and remedies.
Importantly, the increasing relevance of drug interactions due to genetic polymorphisms of metabolizing enzymes and drug transporters and the associated influence of these in ethnic groups is discussed. Also discussed is the risk of interactions in many vulnerable population groups (e.g. infancy, pregnancy, infections, liver and kidney disease).
This quick and easy reference guide brings together the current evidence base with a broad range of practical prescribing experience to produce a source of advice that can be used in the clinic, pharmacy, or at the patient’s bedside.
Table of Contents
1. Drugs Acting on the Cardiovascular System
2. Drugs Acting on the Central Nervous System
3. Anticancer and Immunomodulating Drugs
4. Anticoagulants
5. Antidiabetic Drugs
6. Other Endocrine Drugs
7. Analgesics
8. Musculoskeletal Drugs
9. Anesthetic Drugs: General
10. Drugs to Treat Infections
11. Drugs Acting on the Gastrointestinal Tract
12. Respiratory Drugs
13. Metabolic Drugs
14. Obstetrics and Gynecology
15. Drugs Used to Treat the Urinary System
16. Drugs of Abuse
17. Miscellaneous
18. Over-the-Counter/Online Drugs, Traditional and Herbal Remedies
Appendices:
A. Factors Associated with Drug Effects
B. Factors Associated with Interactions (Polymorphisms, Eicity, Age, Disease States)
C. Foods Implicated in Potentially Severe Interactions
D. Clinical Drug Development
E. Assessments of Manifestations of DDIs
F. Triptan Sensations
G. Assessment of Severity of Liver Disease
H. Prescribing Guidelines for Elderly Patients
I. Factors Affecting Efficacy of Anti-Infective Agents
J. Assessments of Obesity