Book Description
Medication is widely used to support the human body to fight against infection and pain. In an era of pharmaceutical and medicinal challenges, we have all become more familiar with drug production and distribution. However, do we really know what happens before those drugs are distributed? What's the process behind drug discovery? How do our bodies interact with those chemicals? An Introduction to Medicinal Chemistry, 7th edition, offers a complete and accessible approach to this multidisciplinary field. Its student-friendly writing style makes this text an ideal tool for those coming to the subject for first time, but also for students looking to deepen their understanding. The book guides students through understanding the principles of drug action targets in Part A, to how drugs interact at a molecular level with our organs to offer therapeutic value in Part B, and exploring drug design and discovery, as well as regulatory procedures in Part C. Offering a practical approach, Part D provides a deeper look at specific tools and techniques of medicinal chemistry, concluding with emerging topics including antibodies and anticancer agents in Part E. From principles to practice, accompanied by examples and case studies emerging from current biomedical research, the book will equip students with a robust understanding of medicinal chemistry, to prepare them for future success
Table of Contents
1 Drugs and drug targets: an overview
Part A Drug targets: structure and function
2 Protein structure and function
3 Enzymes: structure and function
4 Receptors: structure and function
5 Receptors and signal transduction
6 Nucleic acids: structure and function
Part B Pharmacodynamics and pharmacokinetics
7 Enzymes as drug targets
8 Receptors as drug targets
9 Nucleic acids as drug targets
10 Miscellaneous drug targets
11 Pharmacokinetics and related topics
• Case study 1 Statins
Part C Drug discovery, design, and development
12 Drug discovery: finding a lead
13 Drug design: optimizing target interactions
14 Drug design: optimizing access to the target
15 Getting the drug to market
• Case study 2 The design of ACE inhibitors
• Case study 3 Artemisinin and related antimalarial drugs
• Case study 4 The design of oxamniquine
• Case study 5 Fosmidomycin as an antimalarial agent
Part D Tools of the trade
16 Combinatorial and parallel synthesis
17 In silico drug design
18 Quantitative structure-activity relationships (QSAR)
• Case study 6 Design of a thymidylate synthase inhibitor
Part E Selected topics in medicinal chemistry
19 Antibacterial agents
20 Antiviral agents
21 Anticancer agents
22 Protein kinase inhibitors as anticancer agents
23 Antibodies and other biologics
24 Cholinergics, anticholinergics, and anticholinesterases
25 Drugs acting on the adrenergic nervous system
26 The opioid analgesics
27 Anti-ulcer agents
28 Cardiovascular drugs
• Case study 7 Steroidal anti-inflammatory agents
• Case study 8 Current research into antidepressant agents
• Case study 9 The design and development of aliskiren
• Case study 10 Factor Xa inhibitors
• Case study 11 Reversible inhibitors of HCV NS3-4A protease